background and overview[1]
glyme nickel bromide can be used as a nickel catalyst. glyme nickel bromide can be prepared by the one-step reaction of nibr2 and 1,2 dimethoxyethane.
preparation[1]
under nitrogen protection, mix 10g anhydrous nibr2, 120ml 1,2 dimethoxyethane (dme) and 5ml triethyl orthoformate, heat to reflux for 24 hours, brick red powder will be generated, filter and collect the solid , that is, (dme)nibr2, that is, ethylene glycol dimethyl ether nickel bromide.
apply[2]
a method for synthesizing fenofibrate drug molecules, which is based on 2-methyl-2-(4-carboxyphenoxy)propionate-(1-methylethanol) ester and 1-bromo-4 -chlorobenzene is the substrate, [ir(df(cf3)ppy)2(dtbbpy)]pf6 is the photocatalyst, triphenylphosphine is the deoxidizer, and ethylene glycol dimethyl ether nickel bromide is the nickel catalyst, 4, 4 ‘di-tert-butyl-2,2’-bipyridyl is the ligand, potassium phosphate and cesium carbonate are the base, react in a mixed solvent of n,n-dimethylformamide and acetonitrile under the irradiation of a blue light to obtain a non-toxic norfibrate drug molecule compound: this method has fewer steps, easily available raw materials, and mild reaction conditions.
references
[1] [china invention, china invention authorization] cn201410024754.0 pyrene-4,5,9,10-tetraimine nickel-palladium complex catalyst and its preparation method and application
[2] cn201911420270.7 a synthesis method of fenofibrate drug molecules