background and overview[1]
(r)-2-(o-methyl)benzene-cbs-oxazoborane cas number 865812-10-8, chemical formula 865812-10-8. molecular weight 353.26. density 353.26, boiling point 473.348ºc at 760 mmhg, flash point 4ºc, refractive index 4ºc. (r)-2-(o-methyl)benzene-cbs-oxazoleborane can be used as a pharmaceutical and chemical synthesis intermediate. if (r)-2-(o-methyl)benzene-cbs-oxazoborane is inhaled, move the patient to fresh air; if skin contact occurs, remove contaminated clothing and rinse thoroughly with soap and water. if you feel discomfort on your skin, seek medical attention; if it comes into contact with your eyes, separate your eyelids, rinse with running water or saline, and seek medical attention immediately; if ingested, rinse your mouth immediately, do not induce vomiting, and seek medical attention immediately. advice to protect rescuers is as follows: move the patient to a safe place, consult a doctor, and if conditions permit, please show this chemical safety data sheet to the doctor who comes to the scene. if there is a small leak, collect the leaked liquid in a sealable container as much as possible, absorb it with sand, activated carbon or other inert materials, and transfer it to a safe place. do not flush it into the sewer; if there is a large leak, build a dike or dig a pit. contain, seal the drainage pipe, cover it with foam to inhibit evaporation, use an explosion-proof pump to transfer it to a tanker or a special collector, and recycle or transport it to a waste treatment site for disposal.
structure
preparation [1]
preparation of (r)-2-(o-methyl)benzene-cbs-oxazoborane: r-diphenyl(pyrrolidin-2-yl)methanol from d-proline according to the following method (6). (r)-diphenyl(pyrrolidin-2-yl)methanol (6) is then treated with the corresponding tri-o-tolylboroxane 7 prepared from boronic acid (refluxed in toluene) to obtain the catalytic precursor (r)- 2-(o-methyl)benzene-cbs-oxazoborane was stored in toluene under argon.
main reference materials
[1] (wo2015175994) hiv-1 protease inhibitors and uses thereof