Preparation of D-arabinose-5-phosphate disodium salt_Industrial additives

Background and overview[1]

Arabinose, also known as L(+)-Ganaldose, L(+)-Apentose, pectinose, etc. It is originally a L-monosaccharide extracted from the colloid secreted by the Arabic tree through complex chemical and physical methods. Natural L-arabinose rarely exists free. D-arabinose-5-phosphate disodium salt is an arabinose derivative and can be used as a pharmaceutical synthesis intermediate. If D-arabinose-5-phosphate disodium salt is inhaled, move the patient to fresh air; if skin contact occurs, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical attention if you feel unwell.

Preparation[1]

D-arabinose-5-phosphate disodium salt can be used as a pharmaceutical synthesis intermediate, such as preparing arabinose-5-[(2-hydroxy-3-N, N, N-trimethylammonium) propane [base] phosphate: 2.7g (0.01mol) D-arabinose-5-phosphate disodium salt (manufactured by Sigma Co.), 50g water and 10g 1NHCl were introduced into the reactor and heated to 60°C. Then, 3.0g (0.02mol) glycidyltrimethylammonium chloride solution dissolved in 10g of ion-exchange water was added dropwise within 2 hours while maintaining the reaction system at 60°C. Next, the reaction was carried out at 60°C for 3 hours. After the reaction is completed, the solvent is distilled off under reduced pressure, and the residue is washed with ethanol 10 times the volume of the remaining plastic deodorant residue to remove unreacted glycidyltrimethylammonium chloride. The obtained crude product was purified by ion gas phase silica exchange chromatography (ion exchange resin: AG501X8, trade name, manufactured by BIO-RAD Co.). Thus, 1.1 g of arabinose-5-[(2-hydroxy-3-N,N,N-trimethylamino)propyl]phosphate was obtained (isolated yield: 32%).

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