background and overview[1]
2,5-diaminotoluene dihydrochloride can be used as a pharmaceutical synthesis intermediate. if 2,5-diaminotoluene dihydrochloride is inhaled, move the patient to fresh air; if skin contact occurs, take off contaminated clothing, rinse the skin thoroughly with soap and water, and seek medical attention if you feel uncomfortable.
apply[1]
2,5-diaminotoluene dihydrochloride can be used as a pharmaceutical synthesis intermediate. if the following reaction occurs:
add 2,5-diaminotoluene dihydrochloride (5.85g, 30mmol), triethylamine (6.34g, 63mmol), 2-naphthaldehyde (9.84g, 63mmol) and etoh into a 300ml four-necked flask. (80g), dmso (60g), and stir while heating to 80°c. after the reaction, the precipitate was filtered, washed with etoh (80 ml), and dried to obtain 11.3 g of [t-14] (yellow solid) (yield: 94%). the results of 1h-nmr of the target substance are shown below. based on the results, it was confirmed that the obtained solid was the target.
1hnmr (mhz, cdcl3): δ8.69 (s, 1h), 8.59 (s, 1h), 8.18-8.25 (m, 4h), 7.88-7.96 (m, 6h), 7.52-7.58 (m, 4h), 7.19-7.24(m, 2h), 7.08-7.10(d, 1h), 2.49(s, 3h)
in addition, 2,5-diaminotoluene dihydrochloride can also undergo the following reactions:
add 2,5-diaminotoluene dihydrochloride (5.85g, 30mmol), triethylamine (6.34g, 63mmol), 4-biphenylcarbaldehyde (11.5g, 63mmol) and etoh (80g) and dmso (60g) were heated to 80°c with stirring. after the reaction, the precipitate was filtered, washed with etoh (80 ml), and dried to obtain 12.7 g of [t-15] (yellow solid) (yield: 93%). the results of 1h-nmr of the target substance are shown below. from the results, it was confirmed that the obtained solid was the target [t-15].
1hnmr (mhz, cdcl3): δ8.56 (s, 1h), 8.47 (s, 1h), 7.98-8.06 (t, 4h), 7.71-7.73 (d, 4h), 7.65-7.67 (d, 4h), 7.46-7.50(t, 4h), 7.38-7.41(t, 2h), 7.19(s, 1h), 7.14-7.16(d, 1h), 7.03-7.05(d, 1h), 2.45(s, 1h).
main reference materials
[1] (cn107003577) a composition for manufacturing a liquid crystal aligning film for a transverse electric field driven liquid crystal display element, a liquid crystal aligning film using the composition and a manufacturing method thereof, and a liquid crystal display element having a liquid crystal aligning film and the same manufacturing method